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SCIENCE-DRIVEN SOLUTIONS

Science Behind Our Solutions

Thought leadership in pharmaceutical formulation and manufacturing technology.

Spray Dried Dispersion

Enable challenging molecules through specialized spray dried dispersion capabilities designed for clinical development and scale-up. With expertise in solvent handling, atomization and nozzle optimization, feedstock preparation, and amorphous particle engineering, Forma develops spray dried dispersions engineered to improve solubility, dissolution, and bioavailability across poorly soluble compounds.

  • Enhanced solubility for BCS Class II and IV compounds
  • Polymer screening and selection methodology
  • Scalable from lab to commercial production
  • Micro-evaporative screening for polymer selection and optimization

Hot Melt Extrusion

Hot melt extrusion (HME) offers a solvent-free, continuous manufacturing approach for creating amorphous solid dispersions and sublignual systems. Our twin-screw extruders provide precise control over processing parameters for optimal product quality.

  • Solvent-free continuous processing
  • Precise temperature and shear control
  • Suitable for moisture-sensitive APIs
  • Flexible formulation design capabilities

Modified Release

Our modified release technologies enable precise control of drug release kinetics, from extended-release tablets to complex multi-phase systems. We design formulations that support consistent drug exposure profiles and improved patient adherence.

  • Stabilization strategies for peptides and proteins
  • Combination and layered oral dosage forms
  • High-speed capsule filling and tableting capabilities
  • Controlled-release coating and matrix system development

Oral Biologics

Oral delivery of peptides and enzymes has long been one of the pharmaceutical industry’s greatest formulation challenges. Drawing on decades of experience in oral biologic formulation, Forma applies advanced stabilization, protection, and targeted delivery strategies to support the development of orally available peptide, enzyme, and other biologic therapies.

  • Peptide and enzyme stabilization technologies
  • Enteric protection and gastric resistance systems
  • Protection from enzymatic degradation
  • Bioavailability enhancing oral delivery mechanisms